VS 2008 How do I remove/replace text in a textbox

Hello
I'm a begginer
I want to know how to get my click in button1 to replace remove text
The main I idea is to remove text from - to
Example
In this url : I want to get my click to remove from /me to example
example .com/vb/me/12/16/example/187
Is there anyway ?
Thanks in advance